Sr Scientist/ Principal Investigator- Oligonucleotide Bioanalysis

Company: RPM ReSearch
Location: Saint Louis
Posted on: February 17, 2026

Job Description:

Job Description Job Description Position Title Senior Scientist/ Principal Investigator -Oligonucleotide Bioanalysis We are inviting an accomplished scientist to join our growing drug discovery DMPK and Small Molecule Bioanalysis team. Our site has grown to 120 employees and our team has grown to 8 scientists. We have developed a collaborative culture and mutual respect. Our site is part of a 2400 person growing publicly traded international organization with over 15 sites. We recently made a $4.5MM investment in our site. The DMPK group works in close partnership with disciplines such as medicinal chemistry, pharmacology, toxicology, pharmaceutical sciences, clinical pharmacology, and regulatory to optimize leads, select clinical candidates, conduct preclinical development studies, support clinical evaluation and contribute to IND and NDA filings. This position will be part of a newly created group at our site supporting groups at another site. In the beginning, there will be one person at the site. The goal is to grow the group and this would become a contributing leadership position of the newly formed group. Objectives: Independently designs and implements novel Bio/-analytical methods to support research projects relating to the development of antisense or siRNA Oligonucleotide based therapeutics. Develop and implement innovative high-resolution mass spectrometry-bases metabolite profiling and identification assays. Act as an oligonucleotide bio/-analytical SME and work cross-functionally to build internal capabilities. Position Requirements Education and experience BS or equivalent degree in Chemistry, Biochemistry, or related field, and greater than 15 years of Analytical and/or Bioanalytical Chemistry laboratory experience including study management or, MS in Chemistry, Biochemistry, or related field, and 7 to 10 years of Analytical and/or Bioanalytical Chemistry laboratory experience including study management or, Ph.D. in Chemistry, Biochemistry, or related field and 3 to 5 years of Analytical and/or Bioanalytical Chemistry laboratory experience including study management 5-10 years specific experience with Oligonucleotides Skills and abilities Proven track record of scientific contributions in the development of oligonucleotide analytical and bioanalytical methods to support oligonucleotide delivery platform development. Demonstrates inter-disciplinary knowledge of drug discovery (in vitro/ in vivo pharmacology, ADME, PK/PD, translational research, and toxicology) Working knowledge and awareness of general laboratory procedures. Displays versatility and accuracy performing laboratory operations, some of which may be difficult and/or non-routine. Strong and effective manager and mentor of junior scientists Ability to use a computer to compile and maintain databases for records and inventory, utilizing the appropriate software. Ability to adhere to all safety regulations and procedures. In-depth knowledge and specific understanding of analytical testing needed in drug discovery as it relates to quantitating, characterizing, and further understanding the metabolic fate of ASO and siRNA-based therapeutics and conjugates thereof. Support LC-MS instruments operation, daily maintenance, and troubleshooting. An attitude for quality, an eye for detail, the ability to follow written instructions and work with a minimum of supervision. Full and comprehensive benefits package including Medical/Dental/Vision insurance, 401k, bonus potential, and vacation. This role is a full-time permanent position.

Keywords: RPM ReSearch, Saint Peters , Sr Scientist/ Principal Investigator- Oligonucleotide Bioanalysis, Science, Research & Development , Saint Louis, Missouri